The aim of the present study is to investigate the pharmacokinetics of enrofloxacin and its active metabolite ciprofloxacin after single intravenous and muscle injectionin healthy sheep. There were used 6 Stara Zagora sheep (equal count from both sexes), with body weight between 40 and 42 kg. The enrofloxacin as a hydrochloride salt was applied at a dose of 5 mg/kg for the both ways of administration. Blood samples were collected before and after the injection of the quinolone at 0.08, 0.17, 0.25, 0.50, 1, 2, 3, 4, 6, 8, 10, 12, and 24th h. The plasma concentrations of and its metabolite were determined using a high determined with the use of a computer software TopFit v. 2.0 following the compartment and noncompartment method.
Pharmacokinetics of enrofloxacin after intravenous and intramuscular injection in sheep