4-methylamino-antipyrin (4-MAA) pharmacokinetics was investigated in 6 pigs ( 3 female and 3 male) after intramuscular injection of methamisole (Analginvet 50 % - injection solution) at a dose 25 mg/kg body weight. The plasma concentration of 4-methylamino-antipyrin was determined using high-performance liquid chromatography with UV-detection. The blood concentration of 4-MAA was calculated with a compartmental and noncompartmental method using pharmacokinetic computer software (TopFit, v. 2.0.).
Investigation of pharmacokinetics on marker active metabolite - 4-methylamino-antipyrin (4-MAA) after injection in pigs with drug form Analginvet, containing methamizole