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Based on the experimentai data obtained from the blood serum of one and two year old carps it was found that there are three clearly determined tendencies in the bactericide activity namely – a period of decreasing with values in the range 25.4-29.5.0% which is observed in the end of spring and the beginning of summer, a period of increasing from 62.3% to 74.0% in September and October and a period of relatively stable values in the range from 60.4% to 46.28% starting in November till April. Lysosime activity shows low vaiues in the summer (2.31%) and higher values in the autumn (7.65-15.97%). Lysosime activity is found in 23.2% of the samples of one-year old carp and in 39.6% of the samples of two-year old carp. The values for total protein and total lipids of carp blood serum decrease in the spring (March-April – TP – 23.0 – 28.6 g.l–1; TL – 6.0 – 5.9 g.l–1) and increase in the autumn (October-November – TP – 40.0 – 50.0 g.l–1; TL – 7.5 -11.0 g.l-1).