Tests under field conditions were conducted on the biofertilizer Kompovet and the biological pesticides Neem Oil and Neem Cake on the Gergana cucumber variety and Ismalia F1 zucchini variety. Trials were carried out in 2015-2016, in the village of Kostievo near Plovdiv. The treated variants accumulated more biomass, formed a greater number of female flowers and gave higher yield (by 29.3% and 32.7% respectively) in relation to the control. The plants treated with organic products showed better ecological plasticity to the extremely high summer temperatures. The resulting vegetables contained high values of sugars, carotenoids and chlorophylls compared with the untreated variants and they werе natural sources of phytonutrients of an antioxidant potential. The fruits of the treated zucchini variants showed the highest values of total phenols and performed the highest in vitro antioxidant activity evaluated by the DPPH and FRAP methods. The applied biological pesticides (insecticides and nematicides) increased the resistance to some soil pathogens – root-knot nematodes.