The field trials are conducted in the field with medium-early potatoes during the period 2015–2017. The biological efficacy of six herbicide preparations has been investigated: Zencor 70 BG (metribuzin) – 80 g/da; Dual Gold 960 EK (s-metolachlor) – 150 ml/da; Stomp New 330 EC (pendimethalin) – 400 ml/da; Devrinol 4F (napropropamid) – 400 ml/da; Agile 100 EC (propaquizafop) – 150 ml/da; Panthera 40 EC (quizalofop-P-tefuryl) – 150 ml/da. The system Zencor 70 VG (metribuzin) at a dose 80 g/da + Panthera 40 EC (quizalofop-P-tefuryl) at a dose of 150 ml/da is with the highest efficacy against the weeding, which accounts for the highest percentage of destroyed weeds – 91.4%. In addition, this effect against the weeding in the test area is achieved without a manual hoeing. Systems, which include the soil herbicide Zenkor 70 VG are more efficient compared to other. Under the test conditions, the tested herbicides do not cause phytotoxicityto potatoes of variety Agatha.